A new nasal spray medication, chemically similar to ketamine, will be made more affordable in Australia to aid those with treatment-resistant depression, marking the first major innovation in depression treatment in over three decades. The drug, Spravato (esketamine), works by targeting the neurotransmitter glutamate and can provide rapid relief from depressive symptoms. Available through the Pharmaceutical Benefits Scheme, it will cost $31.60 per dose or $7.70 for concession card holders, enhancing the quality of life for thousands of Australians suffering from this condition.