Sweet 16 Best Bets: Top Picks and Expert Predictions for March Madness

Duke Blue Devils forward Cooper Flagg dunks the ball in the NCAA Tournament against Baylor Bears at Lenovo Center. Best Sweet 16 bets include Alabama vs. BYU with the over, and Duke vs. Arizona with Duke -8.5. Michigan vs. Auburn favors Auburn -8.5, and Purdue vs. Houston leans towards Houston -7.5 due to their strong defense.

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