A major winter storm is set to impact the southern Plains starting Friday, moving across the South and into the East Coast over the weekend. Expect heavy snow, ice accumulation, and dangerously low temperatures affecting nearly 30 states, with potential wind chills of 40-50 degrees below zero. Travel disruptions are likely, particularly in Southern airports lacking deicing equipment, and road conditions will be hazardous on major interstates. Officials recommend avoiding travel unless necessary and preparing with winter storm kits.