Largest pharmacy chain in US closing 271 stores in 2025 – see list

CVS, the largest pharmacy chain in the US, is set to close 271 stores nationwide as part of its enterprise-wide restructuring plan aimed at streamlining operations. The closures, influenced by factors like population shifts and consumer buying patterns, will still leave 85% of Americans within 10 miles of a CVS location. This move follows similar actions from competitors, with Rite-Aid filing for bankruptcy and closing over 800 stores, while Walgreens plans to close 1,200 locations by 2027.

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