The 4-1 San Francisco 49ers face the 4-1 Tampa Bay Buccaneers as 3.5-point underdogs, missing key players including QB Brock Purdy and TE George Kittle. Backup QB Mac Jones is expected to start despite a knee injury, while WR Jauan Jennings, who has been limited in practice due to rib and ankle injuries, may play and could be the primary target if active, otherwise, Kendrick Bourne and Jake Tonges will take on larger roles.
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