Week 3 Straight-Up Picks and Confidence Levels

The NFL Week 3 picks feature notable matchups, including the Bills as 11.5-point favorites against the Dolphins, and two 2-0 teams facing off as the Eagles host the Rams and the 49ers host the Cardinals. High confidence picks include Bills, Packers, and Seahawks, while medium and low confidence picks span several teams, with some underdogs highlighted.

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