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Scientists from Osaka University have discovered a protein, VSP, that responds to changes in membrane potential to regulate sperm maturation, a crucial step in male fertility. By studying VSP in a controlled system using frog egg cells, they found that it activates at -30 millivolts, impacting sperm motility. Mutations affecting VSP’s voltage-sensing ability hindered sperm development, suggesting VSP could be a target for clinical interventions to improve male infertility treatments.
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