Prostate cancer cases in California have been increasing, with a 6.7% yearly rise between 2011 and 2021, while mortality rates declined from 2004 to 2012 and plateaued thereafter. The change in PSA testing guidelines in 2012 may have contributed to the rise in cases of aggressive cancer, prompting experts to emphasize the importance of early screening for better outcomes. Researchers recommend optimized screening methods, including MRI and novel blood-based biomarkers, to identify aggressive cancers while sparing men with low-risk diseases from unnecessary treatment.
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Khamenei of Iran Denounces Negotiation With U.S. but Seems to Leave Door Ajar
Ayatollah Ali Khamenei, Iran’s supreme leader, criticized negotiating with the United States as “unwise, unintelligent, and not honorable,” citing past agreements that were reneged upon. Despite his public stance, Khamenei did not explicitly forbid Iran’s government from engaging in talks with Washington. The comments come amidst escalating tensions, with U.S. officials warning of Iran's nuclear ambitions and President Trump expressing a desire to revive negotiations while also issuing threats against Iran. Full Article
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